Gene Expression Profiling in Postmortem Rett Syndrome Brain: Differential Gene Expression and Patient Classification
The identification of mutations in the transcriptional repressor methyl-CpG-binding protein 2 (MECP2) gene in Rett Syndrome (RTT) suggests that an inappropriate release of transcriptional silencing may give rise to RTT neuropathology.Despite this progress, the molecular basis of RTT neuropathogenesis remains unclear.Using multiple cDNA microarray t